Book C1 Esterase Inhibitor Quantitative Test in Kolkata

Book C1 Esterase Inhibitor Quantitative Test in Kolkata

The body can fight against infections and diseases with the help of antibodies produced by the immune system. An essential part of the immune system is the complement system. The complement system consists of 9 proteins (numbered C1 to C9). These proteins help recognise foreign substances in the body; their deficiency could lead to major health issues. The C1 Esterase Inhibitor Test in Kolkata and other cities is used to detect if there is enough C1-INH protein in the body to produce antibodies to fight diseases.

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About C1 Esterase Inhibitor Quantitative Test

Why is the C1-INH test done?

The doctor suggests individuals get the C1-INH test done if there is any abnormal inflammation or swelling (known as oedema) around the body. The C1-INH is also used to detect hereditary angioedema disease (HAE). The symptoms of HAE include the following:

  • Swelling in various parts of the body, including – feet, hands, face, airway, or gastrointestinal walls
  • Pain in the abdomen
  • Feeling of nausea
  • Unexplained vomiting

The C1-INH test is also used to check how the body reacts to treatment for autoimmune diseases, such as systemic lupus erythematosus (SLE). That helps the doctor determine if any changes are required in the treatment.

What does the C1-INH test measure?

The body has a natural way of combating foreign elements (viruses, bacteria, certain diseases, infections). One such way is through antibodies which are proteins produced by the immune system to destroy these elements.

One of the most crucial components of this immune system of ours is the complement system. The complement system consists of 9 sets of proteins that are labelled C1 through C9. These special proteins are responsible for recognizing foreign threats that have entered the system. When these proteins are not produced in enough quantity due to inhibitors or certain conditions, the body isn’t able to combat diseases, and that leads to major health issues.

The C1-INH test is crucial for testing the level of C1-INH in the body. This is because the C1-INH protein controls the C1 protein that is needed by our body. Therefore, a doctor should be consulted immediately after the test results are received to take the necessary steps.

Risk/Side-effects of C1-INH test

Generally, there is very less risk of any major symptoms inside the body. The person might feel slight pain (or some bruising) in the area where the needle has been pierced to take the blood. But these tend to disappear pretty quickly and not cause any major problems to the patient. In very rare cases, the patient might have blood collection under the skin or develop infection at the site where the needle was pierced. But these are very rare occurrences we should not we worried about.


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Are there any preparations needed for this test?

There are no major preparations needed for the test (preferably stay empty stomach before the test).

How is the sample taken?

The blood is taken from the arm. The area is cleaned by rubbing alcohol, and the technician takes blood precisely.

Are there any risks to the test?

There are minor risks that do not happen under general circumstances. The technicians just need to be a little careful.

Does the body naturally produce antibodies?

The production of antibodies is a natural process that occurs in humans.

Interpreting the C1-INH Test Results

Interpreting the C1-INH Test Results

There is a set range of the normal quantities of C1-INH in the body. That range might vary in certain laboratory results, but does not differ vastly. If there is some abnormality in the quantity of C1-INH in the blood (higher or lower), that could be an indication of the following:

  • Hereditary or genetic angioedema disease (could be acquired as well)
  • SLE (autoimmune disease)
  • Kidney diseases (which include lupus nephritis, glomerulonephritis, membranous nephritis etc.)
  • Blood infection known as septicemia
  • Bacterial infections that are frequent or recurring
  • Malnutrition

When there are abnormalities seen in the C1-INH levels, the doctor might order several other tests to understand the root cause of the problem. For example, higher levels of C1-INH could be due to an ongoing infection. That can be treated with an antibiotic, which should bring the C1-INH level down to normal. However, immediate treatment might be required if there is any serious underlying disease.

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