The mutation tests for Factor V Leiden (FVL) and prothrombin 20210 (PT 20210) are frequently used combined to assist detect the aetiology of an abnormal blood clot (thrombus), such as deep vein thrombosis (DVT) and/or venous thromboembolism (VTE). Factor V Leiden and prothrombin 20210 (PT 20210 or Factor II mutation) are genetic abnormalities linked to an increased risk of abnormal blood clot formation. Two distinct tests that assess a person’s DNA to check for mutations are used to find these mutations. Both tests are frequently used combined to assess whether a person has a hereditary risk of severe coagulation.
If you’ve had one or more instances of abnormal blood clotting, or if you have a significant family background of abnormal blood clots, your doctor may investigate factor V Leiden. After discussing your concerns with your doctor, you might be tested for factor V Leiden (FVL). Special screening and confirmatory blood tests are used to determine the existence of the FVL mutation. Targeted mutation analysis (a type of DNA test) of the F5 gene for the Leiden mutation is the definitive test for FVL. If you frequently have clots or atypical blood clots in your legs or lungs, your doctor may recommend factor V Leiden and prothrombin 20210 tests.
A blood test is used to diagnose factor V Leiden. A screening test to see if you have APC resistance may be done first. Because factor V Leiden is only one of multiple reasons of APC resistance, if your blood shows APC resistance, you may undergo a DNA test (also done on the blood) to discover if you have factor V Leiden. This test will also reveal whether you are heterozygous or homozygous for the condition. The initial screening test for APC resistance is sometimes skipped in favour of a DNA test.
There are little to no known risk factors or side effects attached to the Factor V Leiden Mutation Test
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Your doctor will diagnose FVL by ordering blood tests that are specific for detecting the mutation.
Factor V Leiden is a frequent mutation in a gene that controls the Factor V protein. The Factor V Leiden gene alteration has been associated to an increased risk of blood clots. Factor V is a protein involved in blood clotting.
The result is usually between 50% and 200 percent of the laboratory standard or reference value. The normal value ranges in different laboratories may differ slightly. Some labs may employ different metrics or analyze different samples. Talk to your doctor about the relevance of your specific test results. An individual is heterozygous for the mutation if they have one copy of the factor V Leiden or PT 20210 gene; if they have two copies, they are homozygous for the mutation. Abnormal results include Factor V deficiency, Disseminated Intravascular Coagulation, Liver Cirrhosis, and Secondary Fibrinolysis.
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To book a Factor V Leiden Mutation Test in Delhi, either through word of mouth or by researching online, find different hospitals, clinics, and centres that perform this test. The Factor V Leiden Mutation Test price may vary from place to place and this difference is not very noticeable. Next, you have to find a hospital or lab and pick a time that suits your schedule and either call the clinic or book an appointment online. They will then come to the given address and collect your sample for the test.